Team / Dr. Daniel Leventhal
Daniel S. Leventhal, MS, PhD
Principal Consultant & Immunogenicity Strategy Lead
Immunogenicity Experience
Immunogenicity and technologist leader with over a decade of experience spanning biologics discovery, preclinical development and biotech platform strategy.
Internationally recognized for expertise in immunogenicity risk assessment and mitigation. Extensive experience operating at the interface of immunology, protein engineering, bioanalytics, and computational science to proactively de-risk biologic programs and enable confident development decisions.
- Immunogenicity risk assessment, mitigation, and strategy
- Translational immunology and immune tolerance
- In silico, in vitro, and in vivo immunogenicity tools
- AI/ML and agentic workflows in biologics R&D
Past Experience
I have held positions of increasing responsibility in biologics development organizations, driving strategy and building functions focused on minimizing risk.
- Director, Head of Immunogenicity at Xaira Therapeutics
- Associate Director, Predictive & Translational Biology at Generate Biomedicines
- Led cross-functional strategy spanning technology development and pipeline drug development programs
Education
- PhD, Cancer Biology (Immunology Focus) - University of Chicago
- MS, Translational Sciences - University of Chicago
Selected Publications
The Immunogenicity Database Collaborative (IDC): A standardized, publicly available database for clinical immunogenicity observations and insights.
bioRxiv, 2025
Protein re-surfacing of E. coli L-asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses.
Frontiers in Immunology, 2022
Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage.
Immunity, 2016
How I Work
I believe in data-driven immunogenicity assessment that pairs strategic advisement with hands-on tactical support.
Leveraging deep immunogenicity and immunology expertise paired with experience from AI-native and biologics-focused startups, I guide organizations through digital transformations and the integration of AI models into R&D. My focus is on delivering pragmatic, scalable, and forward-looking solutions.